Given that modulation of CNOT7 expression altered TGF‐β1 secretion in HCC and IFN‐γ secretion by NK cells, and that CNOT7 is a pivotal factor in IFN‐negative regulation, CNOT7 depletion appears to be highly effective in the inhibition of HCC cell proliferation in vitro. The gene discussed is IFNG; the disease is hepatocellular carcinoma.