CYBB and infection: With that in mind, here we provide evidence that NOX2-derived ROS is important to balance NO overproduction during T. cruzi infection, and that inhibition of NOX2, alone, worsens the cardiac outcome, even though other studies have demonstrated that controlling ROS production through NOX2 [74] or through NOX in general [32] controls T. cruzi-induced infection and ameliorates myocarditis.