It showed that DUSP6 protein levels of metastatic tumors were positively correlated with those of primary tumors (R = 0.8666, p < 0.0001), and DUSP6 expression was maintained in the metastatic tumor (Supporting Information Fig. S4d; linear regression equation: y = 0.9359x − 0.5681). Here, DUSP6 is linked to metastatic neoplasm.