We have also identified human homologsand mapped the corresponding genes to human chromosome regions commonly affectedin prostate cancer, with particular attention to thePTEN/HHEX/MXI1 cluster at10q23-25 (frequently deleted in PCa) and to MAPK1 at 22q11.21 (delete inintermediate risk but not in high risk PCa). The gene discussed is MAPK1; the disease is prostate carcinoma.