Smad4, Ikbkb,Rara, ets1, Bhlhe41,Id2, Tnfrsf1a, Mxi1 andDbp are new candidates, together with the well-known tumorsuppressor Pten. As a matter of fact, these genes (except ID2 andMxi1) were found deleted in prostate adenocarcinomas and advanced metastaticprostate cancers. The gene discussed is BHLHE41; the disease is cancer.