In addition to being involved in the inflammatory process in Chagas disease, promoting the fixation of the parasite in the tissues, degranulation of mast cells, and fibrosis, Gal-3 is also associated with neoplasms in several sites, since it is associated with increased invasive capacity, decrease in apoptosis, angiogenesis, and tumor growth. This evidence concerns the gene LGALS3 and Chagas disease.