Lissencephaly (smooth brain) is a brain malformation disorder associated with haploinsufficiency of Lissencephaly-1 (LIS1), also called PAFAH1B1 (Platelet-activating factor acetylhydrolase IB subunit alpha) (Dobyns et al., 1993; Hattori et al., 1994; Reiner et al., 1993; Moon and Wynshaw-Boris, 2013). Here, PAFAH1B1 is linked to lissencephaly spectrum disorders.