S100B and Cachexia: RAGE is a potent inducer of tumour growth and malignant conversion, migration, and invasion in many cachexia‐inducing cancer types; however, a RAGE tumour‐suppressive function has been reported in other cachexia‐inducing cancers.11, 12, 15 Interestingly, (RAGE+ve) LLC tumours developed in Ager−/− mice released smaller amounts of the cachexia‐promoting S100B and were less able to induce reduction of myotube size compared with LLC tumours developed in WT mice.