In certain types of cancer, RAGE and its ligands promote spleen accumulation of myeloid‐derived suppressor cells,43 which have been strongly implicated in development of cancer cachexia, splenomegaly, and poor survival of cancer patients25 and whose activity has been correlated to serum levels of IL‐3 and IL‐17.44 Accordingly, splenomegaly is delayed, and the morphology of spleen is conserved even at 40 dpi in LLC‐Ager−/− mice, in concomitance with low serum levels of IL‐3 and IL‐17. This evidence concerns the gene IL3 and Splenomegaly.