RAGE is a potent inducer of tumour growth and malignant conversion, migration, and invasion in many cachexia‐inducing cancer types; however, a RAGE tumour‐suppressive function has been reported in other cachexia‐inducing cancers.11, 12, 15 Interestingly, (RAGE+ve) LLC tumours developed in Ager−/− mice released smaller amounts of the cachexia‐promoting S100B and were less able to induce reduction of myotube size compared with LLC tumours developed in WT mice. The gene discussed is S100B; the disease is cancer.