F8 and hemophilia A: For comparison, a thrombin generation profile of FVIII‐deficient plasma spiked with recombinant FVIII to a concentration of 2.5% (0.025 U/ml; representing moderate hemophilia A), 10% (0.1 U/ml; representing mild hemophilia A), or 100% (1 U/ml; representing normal plasma) was generated (Fig 2D).