Besides, only in patients with BMI ≥ 24 kg/m2, the risk of CRC in the APC gene rs1804197 A allele carriers was significantly increased (P<0.001), while in the population with BMI < 24 kg/m2, the risk of CRC in the APC gene rs1804197 A allele carriers was decreased (P>0.05). The gene discussed is APC; the disease is colorectal carcinoma.