Moreover, in smokers and non-smokers, the risk of CRC was significantly higher in carriers of the G allele of the rs397768 locus of the APC gene (p < 0.05), and in drinking and non-drinking subjects, the carriers of the G allele of the rs397768 locus in the APC gene did not have an increased risk of CRC (p > 0.05), as shown in detail in Table 4. Here, APC is linked to colorectal carcinoma.