To see whether DANCR was able to distinguish between CRC and colorectal polyps, we compared the two groups and found that at the cut-off value of 1.956, the related sensitivity and specificity of DANCR were 67.5 and 87.5%, respectively with the AUC of 0.745 (95% CI: 0.632–0.859) vs. 0.555 for CEA (95% CI: 0.427–0.684) and 0.542 for CA199 (95% CI: 0.413–0.670) (Figure 4B). Here, CEACAM5 is linked to colorectal carcinoma.