GPT and metabolic dysfunction-associated steatotic liver disease: In both rodents and humans with non-alcoholic fatty liver disease, SGLT-2 inhibitors have been shown to reduce ectopic liver fat by blunting de novo hepatic lipogenesis (596–599), with reduced alanine transaminase (ALT) and aspartate transaminase (AST) levels (600), two markers of hepatic metabolic stress.