RAC1 and cancer: In particular, the small G-protein Rac1 plays a key role in the formation of actin-rich projections, such as lamellipodia and ruffles required for cancer cell motility, and invadopodia which leads to ECM degradation through the deposition of proteases (Cook et al., 2014; Casado-Medrano et al., 2018; Lawson and Ridley, 2018).