According to the first comprehensive molecular profiling of lung adenocarcinomas, the most common somatic mutations in lung adenocarcinomas occur in TP53 (46%), KRAS (33%), KEAP1 (17%), STK11 (17%) EGFR (14%), NF1 (11%), and BRAF (10%), and less frequently in MET, PIK3CA, RB1, CDKN2A among other genes (The Cancer Genome Atlas Research Network, 2018). This evidence concerns the gene RB1 and lung adenocarcinoma.