One interesting example is the activation of rRNA synthesis and tumorigenesis in the nucleolus of lung cancer cells by the GEF Ect2, thus implicating Rac1 in ribosomal biogenesis (Justilien et al., 2017), a process associated with tumor growth, EMT and metastasis (Prakash et al., 2019). This evidence concerns the gene RAC1 and lung cancer.