Similar to most members of the Rho family of guanine-nucleotide binding proteins, Rac1 is a small GTPase (Mw ∼ 21 kDa) that cycles between active GTP-bound and inactive GDP-bound states, and is the most prominently expressed Rac GTPase in lung cancer (Caino et al., 2012). This evidence concerns the gene AKT1 and lung cancer.