Animal studies using mouse models have shown that CTNNB1 is required for proper development of uterine functions, including estrous cycle establishment, embryo implantation, and placental vascularization, while the targeted depletion of CTNNB1 in uterus results in impaired decidualization and infertility (Mohamed et al., 2005; Jeong et al., 2009; Zhang et al., 2012). Here, CTNNB1 is linked to Infertility.