In Figure 7, a heatmap of global uncertainty and sensitivity analysis shows that among 32 parameters, tumor growth rate, T cell exhaustion, cancer killing rate by T cells, TMB, initial tumor diameter, steady-state MDSC density, PD-L1 expression on cancer cells, and inhibitory effect of Arg-I on T cells are significantly correlated with end tumor volume. The gene discussed is CD274; the disease is neoplasm.