Therefore, our study aimed to evaluate whether whole tumor histogram analysis of ADC maps can (I) differentiate WHO grade I and WHO grade II tumors, (II) predict the proliferative potential of those neoplasms and (III) predict the presence of prognostic relevant MGMT (methylguanine-DNA methyl-transferase) promotor methylation and IDH (isocitrate dehydrogenase) mutation status. The gene discussed is MGMT; the disease is neoplasm.