This finding about prevalence of HIV infection in cases with DLBCL was similar to results of a study done at a South African hospital in 2016 which reported the prevalence of HIV as 81% in 139 patients with DLBCL.22 Sixty percent of cases of DLBCL in our study had a CD4 lymphocyte count ≥ 200 cell/μL. The median CD4 count for our DLBCL group was 259 (IQR: 131.2–351.6) cells/μL. This outcome demonstrates that HIV infection placed patients at a higher risk for developing this malignancy and occurrence of the malignancy did not depend on low CD4 count. The gene discussed is CD4; the disease is diffuse large B-cell lymphoma.