Recent studies have shown that nuclear localization of GSK3β is regulated by mTOR complex 1 (mTORC1) (Bautista et al. 2018), and nuclear GSK3β facilitates acute myeloid leukemia (AML) cell growth and drug resistance (Ignatz-Hoover et al. 2018). The gene discussed is GSK3B; the disease is acute myeloid leukemia.