Therefore, hsa_circ_0007843 acted as an miRNA sponge to regulate MMP2 expression by removing the inhibitory effect of miR-518c-5p on MMP2 gene translation, which further affected the invasion and migration of SW480 cells (Figure 6).Our findings suggested that the hsa_circ_0007843/miR-518c-5p/MMP2 regulation axis might play a critical role in the progression and development of colon cancer. This evidence concerns the gene MMP2 and malignant colon neoplasm.