In order to assess the role of CD47 in the development of fatty liver and obesity, we compared hepatic steatosis and subcutaneous fat accumulation in WT and CD47KO mice that were chronically fed LFD (10% kcal from fat) or HFD (45% kcal from fat) for 40 weeks. The gene discussed is CD47; the disease is obesity due to melanocortin 4 receptor deficiency.