ITGAX and systemic lupus erythematosus: In addition, we reported previously that following toll-like receptor 9 (TLR9) and B-cell receptor (BCR) stimulation, CD11c+ B cells from HD were unable to secrete interleukin (IL)-10 (14), while IL-10 is one of the highest messenger RNA (mRNA) expressed found in CD11c+ B cells from SLE patient (12).