The existence of CSCs in NB has been associated with malignancy, resistance to chemotherapy and recurrence (79), as in chemo- and/or radiation-resistant NB cancer stem-like cells an increased expression of the stem cell markers CD133, SOX2, ALDH1, Nestin, OCT4, and NANOG was observed (80). The gene discussed is POU5F1; the disease is neuroblastoma.