Continuous linear growth, delayed bone maturation, tall stature.  Diffuse bone pain, genu valgum.  Cisgender, heterosexual, normal libido.  Normal testicular volume. Normal serum LH and testosterone, increased FSH levels.  Focal hypospermatogenesis on testicular biopsy.  Obesity, acanthosis nigricans, hepatomegaly. Moderate dyslipidemia, Insulin resistance.  Osteoporosis. The gene discussed is BRD2; the disease is obesity due to melanocortin 4 receptor deficiency.