Continuous linear growth, delayed bone maturation, tall stature, eunuchoid body proportions, genu valgum,  Normal libido,  Normal testicular volume  Normal spermogram.  Increased serum basal FSH, with normal LH and testosterone levels.  Overweight, acanthosis nigricans, Dyslipidemia and severe steatohepatitis.  Impaired glucose tolerance and hyperinsulinemia.  Osteopenia. This evidence concerns the gene BRD2 and metabolic syndrome.