Continuous linear growth, delayed bone maturation, tall stature, eunuchoid body proportions.  Diffuse bone pain, genu valgum,  Cisgender, heterosexual, referred normal libido  Bilateral cryptorchidism (surgery unsuccesful at 6 years). Smal inguinal testes, total germ depletion (biopsy).  Normal serum basal LH and testosterone, and increased FSH levels.  Overweight, Dyslipidemia. Type 2 diabetes  Osteoporosis. Here, PLOD1 is linked to metabolic syndrome.