Expression of EGFRvIII in glioblastoma cells also increased SOX9 and FOXG1 mRNA and protein levels (Liu et al., 2015), and thus the increased expression of both transcription factors in EGFR-mediated epigenetic remodeling is a key regulatory network in triggering dedifferentiation to a neural stem cell state. Here, FOXG1 is linked to glioblastoma.