Concomitant elevated FOXG1 and SOX2 expression levels in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators including Foxo3, Polo Like Kinase 1 (Plk1), MYCN Proto-Oncogene (Mycn), DNA Methyltransferase 1 (Dnmt1), Dnmt3b, and Tet Methylcytosine Dioxygenase 3 (Tet3; Figure 1, bottom row; Bulstrode et al., 2017). Here, SOX2 is linked to glioblastoma.