Findings strongly support the participation of NFκβ p65 in the negative regulation of Nrf2 signalling via depriving CBP (CREB binding protein) from Nrf2 or recruitment of Histone deacetylase 3 (HDAC3) on antioxidant recruitment element (ARE) or Mafk providing a new insight into a possible role of NFκβ in suppressing the expression of anti-inflammatory or anti-tumor genes [87]. This evidence concerns the gene MAFK and neoplasm.