For example, both the lncRNA HNF1A-antisense 1 (HNF1A-AS1) and the lncRNA nuclear-enriched abundant transcript 1 (NEAT1) are upregulated in colon cancer tissues, promote the proliferation and invasion of CRC cells and function as ceRNAs to modulate miRNA-34a expression, subsequently causing the repression of the miR-34a/SIRT1 axis [23, 24]. The gene discussed is SIRT1; the disease is colorectal carcinoma.