Zaidi et al. combined anti-CTLA-4 approaches with an antigen-specific DC vaccine in murine PC models and found that this combination significantly elevated vaccine-induced CD4+ T cells as well as CD8+ T cells in PC, providing a novel idea of the combination of vaccine therapy with ICB to drive T cell infiltration in murine PC models [50]. This evidence concerns the gene CD8A and pachyonychia congenita.