For example, the metabolism by ALDH2 and ALDH1A2 has been observed in leukaemia and lung cancer cells overexpressing these enzymes.14 The presence of ALDH1A1, 1A3, 2, 4A1, 5A1, 6A1, 7A1, and 18A1 has been observed in ALDEF‐positive sorted cells.13 Of note, the DEAB used to block ALDEF metabolism and provide a negative control does not present the same selectivity towards all isoenzymes,85 and the isoenzymes do not present the same enzymatic constants. The gene discussed is ALDH2; the disease is lung cancer.