THBS2 and heart failure: THBS2 gene is overexpressed in response to damage or during remodeling in heart failure, hypertensive cardiac disease, hypertrophic heart (Schroen et al., 2004), and atherosclerosis (Streit et al., 1999) and in the context of these diseases may act as an anti‐angiogenic function (Schroen et al., 2004).