Epidemiological studies consistently demonstrated that the expression of GDF15 is up‐regulated with aging (Tanaka et al., 2018) and higher GDF15 relates to poor physical functions (Semba et al., 2019) and higher risk of diabetes, cancer, cognitive impairment, cardiovascular diseases, and mortality (Justice et al., 2018). This evidence concerns the gene GDF15 and Cognitive impairment.