It is of note that a meta‐analysis showed no association between the MMP‐3 5A/6A polymorphism and interbody disk degeneration susceptibility.23 Another SNP (rs632478 polymorphism) was evaluated in an Iranian study,24 which suggested the homozygote CC of the MMP‐3 rs632478 polymorphism may lead to an increased risk for IDD compared with the AA genotype.24 For this study, we only investigated the MMP‐3 gene rs591058 C/T polymorphism. The gene discussed is MMP3; the disease is intervertebral disk degenerative disorder.