High mobility group box protein 1 (HMGB1) is a pro‐inflammatory mediator that upregulates cytokines, chemokines, and adhesion molecules, which, in turn, enhance infiltration of macrophage and cause atherosclerosis.5 Moreover, it has been shown that blockade of HMGB1 results in inhibition of vascular inflammation and alleviation of atherosclerosis in ApoE−/− mice.6 The bioinformatics of Target‐Scan identified that HMGB1 is a potential target for miR‐24 among these target genes. The gene discussed is HMGB1; the disease is atherosclerosis.