HMGB1 and Atherosclerotic lesion: It is also identified as an extracellular trigger to mediate immune response to injury and inflammation.7 The key function ofHMGB1 in the activation of pro‐inflammatory signaling to a variety of cells was widely studied.7 Regarding vascular disorders, it is shown that atherosclerotic lesions have increased levels of HMGB1.8 Moreover, earlier study of our laboratory revealed that VSMC proliferation and migration in vitro could be significantly mediated by HMGB1.9