One study reported that the promoter region of SSTR4, which encodes the somatostatin receptor subtype 4, was more frequently methylated in AD patients than in controls; however, SSTR4 promoter region methylation was not associated with the sum of ACEs categories or with any other factor analyzed in that study (term and course of labor, age and sex, nutritional habits, alcohol drinking severity, cigarette smoking) [20]. Here, SSTR4 is linked to Alzheimer disease.