Furthermore, a primary sample database of HLA ligandome data from various cancer entities (552 samples with 245 HLA-A*02:01-positive donors) and benign tissue samples (404 samples with 172 HLA-A*02:01-positive donors) was screened for naturally presented Cyclin A1-derived HLA-A*02:01-restricted ligands. This evidence concerns the gene CCNA1 and cancer.