CD4 and type 1 diabetes mellitus: In addition, lower frequencies of CD4+ T cells with a central memory phenotype (CD27intCD127+CD95int) were present in slow progressors compared with healthy donors, whereas higher frequencies of CD4+ T cells with a central memory phenotype (CD27intCD127+CD95int) were detected in people with newly diagnosed type 1 diabetes compared with healthy donors, consistent with an earlier report [23].