All of the four lymphocytic reaction components were positively associated with proximal location, early disease stage, well-to-moderate tumour differentiation, MSI-high status, CIMP-high status, LINE-1 hypermethylation, BRAF mutation, negative nuclear CTNNB1 expression and high neoantigen load (all P < 0.005). Here, CTNNB1 is linked to neoplasm.