CD8A and hepatocellular carcinoma: Other drivers of T-cell exhaustion in HCC include LAG-3, associated to hypofunctional CD8+ responses in HCC TILs, which can be reversed upon LAG-3 blockade [53] and B and T-lymphocyte attenuator (BTLA), seen in >50% of PD-1+ TILs in HCC and denoting particularly pronounced hypo-functionality [54] and T-cell exclusion [55].