Increased expression of TH2 cytokines (IL-4, IL-5 and IL-10) is associated with disease progression and metastasis in HCC [35] as a likely consequence of IL-4-mediated recruitment of TAM, which in turn secrete TGF-β and vascular endothelial growth factor (VEGF) [35]. Here, VEGFA is linked to hepatocellular carcinoma.