While GATA6 suppression did not affect CC10+ derived hyperplasia in K mice, it reduced the burden of CC10-Cre KP lesions, which may be due to the requirement for SPC+ cells at later stages of CC10-Cre tumor progression, and/or a requirement for Gata6 in CC10-derived tumors that also have lost p53. Here, GATA6 is linked to neoplasm.