A previous report showed that the expression of lncRNA NEAT1 was significantly increased in non-alcoholic fatty liver disease (NAFLD) models in vivo and in vitro, while downregulation of lncRNA NEAT1 alleviated NAFLD through the mammalian target of rapamycin/S6K1 signaling pathway23. This evidence concerns the gene MTOR and metabolic dysfunction-associated steatotic liver disease.