The enriched inflammatory pathways in the GL-vDG were CRTH2 signalling in Th2 cells, MIF (the neuroendocrine-macrophage connector), function of MEF2 in T lymphocytes, IL-16 signalling pathway, reactive oxygen species (ROS) in IL-4 signalling, IL-3 signalling via ERK and PI3K, regulatory role of C1q in platelet activation, MIF-JAB1 signalling, and NETosis in SLE. Here, IL16 is linked to systemic lupus erythematosus.