For example, facial infiltrating lipomatosis and CLOVES syndrome (congenital lipomatous overgrowth with vascular, epidermal, and skeletal anomalies) are caused by somatic PIK3CA mutations and exhibit overgrowth of every tissue (i.e., skin, subcutis, muscle, bone, cartilage)10,11. The gene discussed is PIK3CA; the disease is CLOVE syndrome.