Recently, Fan J’s team has sequenced 159 Chinese patients with HCC and found that the mutation frequency of AXIN, TSC2, SMARCA2, ATRX, KMT2C is higher than that of HBV-related diseases reported by TCGA, while CTNB1, ARID1A and RB1 is lower, suggesting that the mutation spectrum of HBV-related HCC population in China is different from that in Western countries, which is the same in 10 HCC patients in our center27. The gene discussed is RB1; the disease is hepatocellular carcinoma.