Recently, Fan J’s team has sequenced 159 Chinese patients with HCC and found that the mutation frequency of AXIN, TSC2, SMARCA2, ATRX, KMT2C is higher than that of HBV-related diseases reported by TCGA, while CTNB1, ARID1A and RB1 is lower, suggesting that the mutation spectrum of HBV-related HCC population in China is different from that in Western countries, which is the same in 10 HCC patients in our center27. This evidence concerns the gene TSC2 and hepatocellular carcinoma.