Afterwards, more and more studies have focused on the anti-cancer effects of JQ1 in solid tumors, and found that JQ1 suppressed tumor growth via transcriptionally inactivating multiple oncogenic pathways other than c-MYC, e.g., YAP, Akt, and NOTCH3, in various cancer types including pancreatic cancer, colorectal cancer, prostate cancer, and breast cancer26–28. This evidence concerns the gene NOTCH3 and familial pancreatic carcinoma.