CAF-specific FAK depletion was confirmed by the following: epithelial cells isolated from breast tumours grown in MMTV+;FSP-Cre+;FAKfl/fl or MMTV+;FSP-Cre−;FAKfl/fl mice had no detectable differences in FAK expression levels (Supplementary Fig. 2d, Supplementary Fig 7); using CAG-tdTomato reporter mice, the vast majority (94.8%) of tdTomato-positive cells are CD45 negative (Supplementary Fig. 2e); depletion of FAK was not observed in BMDMs in FSP-Cre+;FAKfl/fl mice (Supplementary Fig. 2f, g, Supplementary Fig 7). The gene discussed is PTPRC; the disease is breast neoplasm.