S100A4 and neoplasm: In vivo evidence of this upregulation of chemokines was also found since Ccl6 and Ccl12 transcript levels were upregulated in FSP-1-positive CAFs in tumour sections from MMTV+;FSP-Cre+;FAKfl/fl compared with control mice, demonstrating their regulation by CAF-FAK in vivo (Fig. 5f).