PTK2 and neoplasm: Furthermore, exposure of BMDMs to FAK-depleted CAF CM for 3 h increased glycolytic capacity and glycolytic reserve significantly (Supplementary Fig. 6c) suggesting that although FAK-depleted CAF CM is sufficient to induce modest metabolic alterations in macrophages, tumour cell-derived factors are very likely involved in enhanced glycolysis in BMDMs upon depletion of FAK in CAFs.