Of note, CCR1 and CCR2 are members of the family of G-protein coupled receptors (GPCR)35 and enhanced GPCR signalling through Gαs and Gα12/13 was also observed in the epithelial compartment of patient tumours with low stromal FAK correlating low stromal FAK expression, cancer progression, enhanced metabolism with elevated signalling via GPCRs in human cancer (see Fig. 4e). This evidence concerns the gene CXCR6 and neoplasm.