RAP1A and breast cancer: The clinical relevance of these signalling changes was demonstrated by the elevated transcription of genes encoding the regulatory subunit of PKA (PRKAR1A), Rap1A, Kinase suppressor of Ras (KSR), MAP2K3 (MKK3), small GTPase Rac1, CTNBB1 (beta-catenin) and LEF1 in the epithelial compartment of human breast cancers with low levels of stromal FAK (Fig. 6 h).