CGAS and Hutchinson-Gilford progeria syndrome: Our initial analysis suggested that Banf1 might act analogously to other recently described genes that modulate cGAS activation, type I IFN production, and ISG expression, including Trex1 (30), ATM (31), LATS1/2 (32), and STAG2 (26), as well as the genes causing Fanconi anemia (33) and Hutchinson-Gilford progeria syndrome (34).