To obtain a functional validation in the current study, we incubated B16F10 melanoma cells with WT platelets with or without 1 μM of ARC39, platelets from Asm−/− mice, and rhASM with or without 1 μM of ARC39 and determined the adhesion of melanoma cells to fibronectin-coated cover slips. The gene discussed is FN1; the disease is melanoma.