NR3C1 and chronic primary adrenal insufficiency: Interestingly, GCs can inhibit the transcription of steroidogenic genes through a mechanism that involves increase in the expression of the steroidogenic co-repressor dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1) (Gummow et al., 2006) as well as by inhibiting both the transcription and the activity of Nur77 via a mechanism that involves active GR (Song et al., 2004, Martin and Tremblay, 2008).