SYP and neuroendocrine neoplasm: The 2003 WHO classification of breast tumors recognizes neuroendocrine carcinoma as a distinct histological entity, with the same morphological characteristics as neuroendocrine tumors of the gastrointestinal tract, pancreas, and lung, with more than 50% positive immunostaining of tumor cells by a neuroendocrine marker such as chromogranin or synaptophysin [4]..