Based on RNA-Seq analysis, Tian et al. [10] identified differentially expressed transcripts in DCIS models, which are associated with signaling pathways such as cell proliferation, cell-cell adhesion, and cell-cell signaling, and reported that aldehyde dehydrogenase 5A1 (ALDH5A1) may serve as a novel molecular target in DCIS treatment. The gene discussed is ALDH5A1; the disease is ductal breast carcinoma in situ.