Furthermore, gene mutations in DCIS have also been associated with the progression of DCIS; these include BRCA1/2 deleterious mutation [7], somatic mutations in AKT1, PIK3CA, and TP53 [8], and hypermethylation of HOXA5 and SOX genes [9]. The gene discussed is HOXA5; the disease is ductal breast carcinoma in situ.