Through VENN analysis, we detected 603 upregulated and 1043 downregulated DEGs overlapping in the three cancer cell lines (Fig. 2), including 16 upregulated TFs (e.g., HOXA2, HOXB2, HOXC10, and NKX2-1) and 36 downregulated TFs (e.g., BACH1 and CDX1), respectively. Here, NKX2-1 is linked to cancer.