After adjusting for confounding factors related to HBP (diabetes mellitus, hypertension, atrial fibrillation, heavy smoking, type of cardiac surgery and CPB time), there was a positive correlation between HBPCS2 and cTnTCS2 (B = 48.74, β = 0.43, P < 0.01) or peripheral arterial cTnT levels at 5 min after aortic declamping (B = 38.91, β = 0.21, P = 0.02), at T0 (B = 65.13, β = 0.32, P < 0.01), T3 (B = 100.38, β = 0.52, P < 0.01), T24 (B = 102.29, β = 0.48, P < 0.01), and T48 (B = 165.31, β = 0.84, P < 0.01) and T72 (B = 98.63, β = 0.40, P < 0.01). The gene discussed is TNNT2; the disease is diabetes mellitus.