LncRNAs, such as HOX transcript antisense RNA (HOTAIR), growth arrest specific 5 (GAS5), urothelial cancer associated 1 (UCA1), HOXA transcript at the distal tip (HOTTIP), and X-inactive specific transcript (XIST), were found to play an important role in HCC at different levels [34-38]. The gene discussed is UCA1; the disease is hepatocellular carcinoma.