Given that mdx mice were treated with the ADAMTS-5 mAb between 4 and 7 weeks of age, it is impossible to discern from H&E stained EDL cross-section which centrally nucleated fibers represent repair from that initial bout of myonecrosis at 3 weeks of age and which are indicative of more recent damage and repair [35]. The gene discussed is ADAMTS5; the disease is gas gangrene.